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At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
About Bristol-Myers Squibb
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, immunology, hematology, and cardiovascular disease.
Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration, and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.
Mechanisms of Cancer Resistance (MoCR) Translational Research (TR)
The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists in MoCR focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo, and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making for early development POC.
San Francisco, CA
We are seeking an individual with translational expertise to join the Translational Research (TR) team within the Mechanisms of Cancer Resistance Thematic Research Center (MoCR TRC) at Bristol-Myers Squibb in San Francisco, CA. The qualified candidate is highly motivated, interactive, creative, and can work across a highly matrixed organization to advance programs from lead initiating/optimization through IND enabling activities and ultimately to Clinical Proof of Concept.
This individual will be responsible for delivering and executing on translational and biomarker plans for MoCR TRC programs. This individual will bring scientific experience with emphasis on oncology biomarkers, knowledge of oncology & clinical development, and expertise in matrix-based management. This individual will deliver biomarker and translational strategies from lead optimization through clinical Proof-of-Concept (PoC), including creating/running assays for target engagement, pharmacodynamic (PD) markers, and patient enrichment strategies.
- Establish and execute translational biomarker strategies for development candidates within the MoCR TRC with a focus on pharmacodynamics, mechanism-of-action, and patient stratification/selection
- Work cross-functionally to interact closely with groups including small molecule drug discovery, translational medicine, early clinical development, and project leadership to deliver high-quality biomarker plans
- Provide scientific input and review biomarker aspects of early clinical development plans, clinical study reports, and regulatory documents
- Lead efforts on data generation, interpretation, and communication
- Find new ways to support biomarker plans, to enable early understanding of lead molecules, as they move from discovery through early development
- Ensure that biomarker plans meet established program standards (within budget, on schedule, compliance, etc.)
- Communicate key biomarker program information, risks, and milestones, within team and continues to define, revise and progress biomarker plans as projects progress
- Ph.D. in cancer biology, immuno-oncology, or equivalent advanced biology degree and at least 3 years of industry experience in oncology drug development (small molecule and biologics)
- Translational experience in the discovery and implementation of pharmacodynamic and predictive biomarkers using preclinical models, both in vitro and in vivo, and in clinical trials
- Intimate knowledge of and extensive hands-on experience with relevant molecular and cell biology techniques along with biochemical and cell-based assays
- Experience in the field of chromatin biology and transcriptional regulation is a plus
- Excellent verbal and written communication skills
- Ability to recognize, articulate, and accept calculated risks to make informed decisions
- Comfortable working in a fast-paced environment where speed is paramount
- Demonstrated experience in appropriate application of various scientific technologies into translational research strategies
- Demonstrated ability to effectively influence stakeholders in a dynamic, matrixed organization
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.